In 1972, the fully equipped "Shimizu Research Center" became KAKETSUKEN's Headquarters taking the place of the Kyomachi Research Center. On the premises of approximately 147,000m 2 , there are a Y-shaped main building, a plasma fractionation production building, a vaccine production building, a management building, an employee hall, and other buildings. In 2005, a building for the filling facility（Building NR） was newly completed. Blessed with a contemporary biotechnology environment, each department of research, production, sales, pharmaceutical affairs, and management, is fully equipped.

The Kikuchi Research Center was established in 1985 for research and development in the "Bioforest" of the Kumamoto Technopolis Project. The Center has invented various advanced technologies as groundwork for biotechnology, playing a key role in the Kumamoto Technopolis Project. The vast premises of approximately 248,000m 2 comes complete with a main research building, a GLP building, an applied research and Manufacturing building, and an welfare hall, among other buildings. In 2005,completion of the recombinant albumin（factory KR） factory.

On the 118,000m2, premises, with Mt. Aso in the background, there is a management building, a stable, a specific pathogen free (SPF) chicken house, a duck house, and a pig pen. SPF animals, snake venom, and antitoxic serums are produced here. In 2003, completion of the Aso lab for the production of antitoxins.

Substantial Health and Welfare Facilities
The "Fureai" employees hall at the Headquarters, and the "Komorebi" employees hall at the Kikuchi Research Center.

KAKETSUKEN regards healthy, cheerful, and fulfilled employees as important strengths in developing superior products. Accordingly, we have emphasized the health and welfare of our staff. With the aim of fostering the healthy minds and bodies of our employees, a welfare (employees) hall was established in both the Headquarters and the Kikuchi Research Center, based on the special welfare fund system of the labor-management agreement. The "Komorebi," completed in 1994, is the employee hall of the Kikuchi Research Center, with a gross floor area of approximately 2,300 m2, having two stories above ground and one below. There is an exercise room in the basement of the Komorebi, and on the first floor a cafeteria with a seating capacity of 250, a Japanese-style room, and a shop. The second floor is made up of meeting rooms and a lounge area. These facilities provide work break areas for our staff.

As part of the Nonprofit activities, KAKETSUKEN established the Health Laboratory Technician Training institute in 1959. This soon changed to the Educational Corporation Ginkyo-Gakuen, the Ginkyo Junior College (three year system) followed by the establishment of the 4 year university in April 2003. 2 main faculties, Hygiene Technological Department and Nursing Department are available in this institution to train future Medical Technicians.

With a total of 238 beds, this hospital consists of clinical divisions of internal medicine, neurogy, respiratory organs, orthopedic surgery, rehabilitation, dermatology, and psychiatry, for wide-ranging medical treatments.