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| 1945.12 |
Established in Komeya-machi in Kumamoto City with the Institute of Experimental Medicine before World War2 , KAKETSUKEN was founded to produce and supply vaccines, antiserums, and diagnostic antigens in response to a proposal by Prof. T. Otawara of the Kumamoto Medical College. |
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| 1946.03 |
Moved to Furukyo-machi (Kumamoto castle, Sannomaru) in Kumamoto City as a start to the expansion of facilities. |
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| 1950.10 |
Vaccines for animals first produced. |
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| 1953.11 |
Blood Center established. Blood banks operated in various parts of Kyushu, contributing to emergency medical care. (Operation stopped in 1967). |
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| 1959.06 |
The KAKETSUKEN Sanitary Inspecting Engineers Training School established.
(Currently, Ginkyo Gakuen College). |
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| 1962.10 |
The Aso Branch Laboratory established. |
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| 1966.08 |
Blood plasma products first produced. Facing challenges as a new department, KAKETSUKEN made full use of its expertise accumulated through the operation of blood banks. |
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| 1969.09 |
The Shimizu Research Center established to enhance the strength of research and development as well as production.
To create a system for expanding business, the Shimizu Research Center became KAKETSUKEN's Headquarters in 1977. |
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| 1980.02 |
"Venilon," a human immunoglobulin product for intravenous injection is marketed. Venilon is widely used and is still a product in high demand. |
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| 1981.08 |
A building for the production of blood plasma products (Building S) completed. |
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| 1985.11 |
The Kikuchi Research Center constructed. Commenced enterprises including research and development in the field of biotechnology. |
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| 1988.03 |
Commenced production of "Bimmugen," a recombinant hepatitis B vaccine. This product became Japan's first recombinant drug produced with exclusively Japanese technology. |
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| 1991.11 |
"Bolheal," Japan's first tissue adhesive for living tissue, is marketed. |
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| 1993.01 |
Completion of a building for the production of vaccines (Building G). |
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| 1993.10 |
"Oil Vax," an oil adjuvant vaccine for fowl, is marketed. |
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| 1996.07 |
The development of cultivated forests for water resources to secure the underground water supply in Kumamoto launched. |
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| 1999.03 |
Completion of a building for the production and preparation of vaccines (Building R). |
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| 1999.04 |
Absorbed the business end of KAKETSUKEN CO.,LTD. |
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| 2001.11 |
ISO 14001 certificate obtained. |
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| 2001.12 |
A building for the production of blood plasma products(Building NS)completed. |
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| 2002.07 |
Due to the closure of the Chiba Therapeutic Research Institute, succeeded right to produce 6 products include smallpox vaccine. |
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| 2002.12 |
Completion of the influenza vaccine production(Building F) building. |
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| 2003.12 |
Completion of the Aso lab for the production of antitoxins. |
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| 2005.04 |
"Oil Vax SET," an oil adjuvant vaccine for fowl, is marketed. |
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| 2005.10 |
Completion of the recombinant albumin (factory KR) factory. |
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| 2005.11 |
Completion of the filling facility (Building NR). |
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